I hope you do go, i have finally got all my answers from them,
here is about the islet transplant
What to Expect
During a pancreatectomy and auto islet transplant, surgeons remove the patient’s pancreas. Then, they isolate the islets from the pancreas and infuse the islets back into the patient’s portal vein in the liver. The islets lodge in the liver or spleen and start producing insulin.
About half of patients who have this procedure do not need to take insulin. Our experience indicates that if the patient has had previous surgery on the head or tail of the pancreas, they are more likely to need to take insulin shots after the pancreatectomy and auto islet transplant.
Because the patient’s own islets are used, they do not need to take immunosuppressive medications after surgery.
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Our most recent results, which were presented at the 2005 annual Clinical Congress of the American College of Surgeons, indicate that a pancreatectomy and auto islet transplant can provide significant pain relief to most patients with chronic pancreatitis. In a study of 140 patients who had undergone pancreatectomy for pain associated with chronic pancreatitis, about 63% of patients had complete pain relief and 22% had partial pain relief. The remaining 15% of patients indicated that they had no change in the degree of pain after surgery.
Typically, patients who have had a pancreatectomy become diabetic after the surgery. During a pancreatectomy, the patient’s pancreas is removed. The pancreas contains islets which produce insulin. Without an external source of insulin (such as insulin injections or an insulin pump), a patient who had a pancreatectomy would not survive.
However, at the University of Minnesota Medical Center, a patient can have a procedure called an autoislet transplant after their pancreatectomy. This procedure reduces the patient’s need to inject themselves with insulin to manage their diabetes. During an autoislet transplant, the patient’s islets are isolated from the rest of their pancreas and then transplanted back into them. Islet isolation is a very sophisticated process performed in a laboratory that meets the Good Manufacturing Practice standards set by the U.S. Food and Drug Administration. At present, the University of Minnesota Medical Center is one of only two hospitals that routinely performs pancreatectomy and auto islet transplants for patients with chronic pancreatitis.
Among 51 patients who received more than 2,000 islet equivalents per kilogram, 72% could manage their diabetes without regular injections of insulin. Of these patients, about 47% did not need insulin at all after their surgery and 25% needed only intermittent insulin treatments.
In conclusion, a total or near total pancreatectomy effectively treats pancreatitis pain in most patients who have not received relief of pain through medical management or other procedures. Auto-islet transplantation is a safe addition to extensive pancreatic resection that can prevent surgically induced diabetes, fulfilling the principle of preserving pancreatic function and relieving pain to the fullest extent possible. Patients undergoing pancreatectomy, even with an auto-islet transplant, must be willing to accept diabetes for relief of pain, but an attempt to prevent diabetes should always be made by performing an auto-islet transplant. Read more about our most recent results.
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